Jeffrey R. Strawn, MD is Professor of Psychiatry & Behavioral Neuroscience in the College of Medicine, University of Cincinnati, Cincinnati, Ohio.

Introduction; List of icons; Abbreviations; 1. The case: the salutatorian who couldn't speak: Selective Serotonin Reuptake Inhibitor (SSRI)-refractory anxiety in an adolescent; 2. The case: from anxious to activated: Selective Serotonin Reuptake Inhibitor (SSRI)-related activation; 3. The case: the girl who couldn't sleep: Posttraumatic Stress Disorder (PTSD) in a young girl; 4. The case: depressed and still depressed: Major Depressive Disorder (MDD) in an adolescent; 5. The case: a 13-year-old adolescent who feels 'amazing': Selective Serotonin Reuptake Inhibitor (SSRI)-induced mania in an adolescent; 6. The case: counting on a cure: Obsessive-Compulsive Disorder (OCD) in an adolescent; 7. The case: struggles in the second grade: Attention-Deficit Hyperactivity Disorder (ADHD) in a child; 8. The case: from prodrome to psychosis: early-onset schizophrenia; 9. The case: too much, too little, or just right? lithium dosing in an adolescent; 10. The case: tic, tic, tic: motor and vocal tics in a boy; 11. The case: how slow can you go? Selective Serotonin Reuptake Inhibitor (SSRI) withdrawal and discontinuation in an adolescent; 12. The case: the adolescent who doesn't eat: anorexia nervosa in an adolescent; 13. The case: high or higher antidepressant concentrations? cannabis-related drug interactions in an adolescent; 14. The case: the boy whose bed was always wet: nocturnal enuresis in a child; 15. The case: counting sheep and counting treatment trials: insomnia disorder in an adolescent; 16. The case: Second-Generation Antipsychotics (SGAs), side effects, and the autism spectrum: SGA-related side effects in a boy with Autism Spectrum Disorder (ASD); 17. The case: the 'standard treatment' is earning a 'D': treatment-resistant schizophrenia; 18. The case: symptoms, side effects, or both? Selective Serotonin Reuptake Inhibitor (SSRI) tolerability and physical symptoms in an anxious adolescent; Index.