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Circadian Pharmacokinetics
Taschenbuch von Baojian Wu (u. a.)
Sprache: Englisch

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Beschreibung
This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
Über den Autor

Dr. Baojian Wu is a professor at the College of Pharmacy, Jinan University, China. He obtained his Ph.D. from University of Houston in 2011 and completed his post-doctoral training at the Baylor College of Medicine from 2011 to 2012. His research focuses on circadian regulation of drug metabolism and transport, as well as circadian regulation of inflammatory and metabolic diseases, fields in which he has published more than 100 research articles.

Dr. Danyi Lu is an associate professor at the College of Pharmacy, Jinan University, China.

Dr. Dong Dong is an associate professor at the College of Medicine, Jinan University, China..

Zusammenfassung

Reinforces basic knowledge and principles on circadian clock and metabolic diseases

Enriches understanding of circadian regulation of drug metabolism and transport

Serves as a helpful reference and provides implications of circadian pharmacokinetics in chronotherapeutics

Inhaltsverzeichnis
Chapter 1. Introduction to mammalian circadian clock system.- Chapter 2. Introduction to pharmacokinetics.- Chapter 3. Circadian clock and metabolic diseases.- Chapter 4. Circadian clock and CYP metabolism.- Chapter 5. Circadian clock and non-CYP phase I metabolism.- Chapter 6. Circadian clock and phase II metabolism.- Chapter 7. Circadian clock and uptake transporters.- Chapter 8. Circadian clock and efflux transporters.- Chapter 9. Role of pharmacokinetics in chronotherapeutics.- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.
Details
Erscheinungsjahr: 2021
Fachbereich: Toxikologie
Genre: Importe, Medizin
Rubrik: Wissenschaften
Medium: Taschenbuch
Inhalt: vii
253 S.
13 s/w Illustr.
46 farbige Illustr.
253 p. 59 illus.
46 illus. in color.
ISBN-13: 9789811588099
ISBN-10: 9811588090
Sprache: Englisch
Einband: Kartoniert / Broschiert
Redaktion: Wu, Baojian
Dong, Dong
Lu, Danyi
Herausgeber: Baojian Wu/Danyi Lu/Dong Dong
Auflage: 1st edition 2020
Hersteller: Springer Singapore
Springer Nature Singapore
Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße: 235 x 155 x 15 mm
Von/Mit: Baojian Wu (u. a.)
Erscheinungsdatum: 29.10.2021
Gewicht: 0,406 kg
Artikel-ID: 120674233
Über den Autor

Dr. Baojian Wu is a professor at the College of Pharmacy, Jinan University, China. He obtained his Ph.D. from University of Houston in 2011 and completed his post-doctoral training at the Baylor College of Medicine from 2011 to 2012. His research focuses on circadian regulation of drug metabolism and transport, as well as circadian regulation of inflammatory and metabolic diseases, fields in which he has published more than 100 research articles.

Dr. Danyi Lu is an associate professor at the College of Pharmacy, Jinan University, China.

Dr. Dong Dong is an associate professor at the College of Medicine, Jinan University, China..

Zusammenfassung

Reinforces basic knowledge and principles on circadian clock and metabolic diseases

Enriches understanding of circadian regulation of drug metabolism and transport

Serves as a helpful reference and provides implications of circadian pharmacokinetics in chronotherapeutics

Inhaltsverzeichnis
Chapter 1. Introduction to mammalian circadian clock system.- Chapter 2. Introduction to pharmacokinetics.- Chapter 3. Circadian clock and metabolic diseases.- Chapter 4. Circadian clock and CYP metabolism.- Chapter 5. Circadian clock and non-CYP phase I metabolism.- Chapter 6. Circadian clock and phase II metabolism.- Chapter 7. Circadian clock and uptake transporters.- Chapter 8. Circadian clock and efflux transporters.- Chapter 9. Role of pharmacokinetics in chronotherapeutics.- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.
Details
Erscheinungsjahr: 2021
Fachbereich: Toxikologie
Genre: Importe, Medizin
Rubrik: Wissenschaften
Medium: Taschenbuch
Inhalt: vii
253 S.
13 s/w Illustr.
46 farbige Illustr.
253 p. 59 illus.
46 illus. in color.
ISBN-13: 9789811588099
ISBN-10: 9811588090
Sprache: Englisch
Einband: Kartoniert / Broschiert
Redaktion: Wu, Baojian
Dong, Dong
Lu, Danyi
Herausgeber: Baojian Wu/Danyi Lu/Dong Dong
Auflage: 1st edition 2020
Hersteller: Springer Singapore
Springer Nature Singapore
Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße: 235 x 155 x 15 mm
Von/Mit: Baojian Wu (u. a.)
Erscheinungsdatum: 29.10.2021
Gewicht: 0,406 kg
Artikel-ID: 120674233
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