Michael M. Cox is Assistant Chair, Department of Biochemistry at the University of Wisconsin-Madison. He received his B.A. in Biology from the University of Delaware and his Ph.D. in Biochemistry from Brandeis University. Coxs current research activity involves studies of the mechanism of action of proteins involved in genetic recombination. This work is focused on the bacterial RecA protein, the bacterial RecF, RecO, RecR, RecG, RuvA, and RuvB proteins, the yeast Rad 51 protein, and more broadly on the mechanism of the recombinational DNA repair of stalled replication forks.

Jennifer A. Doudna grew up on the Big Island of Hawaii, where she became interested in chemistry and biochemistry during her high school years. She is currently Professor of Molecular and Cell Biology and Professor of Chemistry at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute. She received her B.A. in biochemistry from Pomona College and her Ph.D. from Harvard University, working in the laboratory of Jack Szostak, with whom she also did postdoctoral research.

Michael ODonnell received his Ph.D. at the University of Michigan, where he worked under Charles Williams Jr. on electron transfer in the flavoprotein thioredoxin reductase. He performed postdoctoral work on E. coli replication with Arthur Kornberg and then on herpes simplex virus replication with I. Robert Lehman, both in the biochemistry department at Stanford University. ODonnell then became a member of the faculty of Weill Cornell Medical College in 1986 and an investigator at the Howard Hughes Medical Institute in 1992 before moving to The Rockefeller University in 1996. ODonnell is a member of the National Academy of Sciences.

• Throughout each chapter, special features focus on fascinating topics that enhance student understanding of the concepts
• Medicine looks at diseases that arise from defects in biochemical pathways, or examples of how concepts learned in molecular biology have contributed drug therapies or other treatments
• Technology focuses on cutting-edge molecular biology methods that students will likely be hearing about or even using in the future
• Evolution reveals the role of molecular biology research in understanding key biological processes and the connections between organisms
• A Closer Look highlights a wide variety of additional, intriguing topics

New_to_this_edition

• The second edition addresses recent discoveries and advances, corresponding to our ever-changing understanding of molecular biology
• There are numerous new figures and photos, along with significantly updated figures in every chapter
• There are also new end-of-chapter questions for every chapter and many new Unanswered Questions.

I. Foundations

II. Nucleic Acid Structure and Methods

III. Information Transfer

IV. Regulation