Relevance of the aging suppressor protein ...

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Sprache: Englisch

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Beschreibung

The Klotho protein is known to be involved in premature aging as an aging suppressor. Overexpression of the Klotho gene extends lifespan in mice and defective Klotho results in rapid aging and early death. Both the membrane and secreted forms of Klotho have biological activity. Klotho serves as a co-receptor for fibroblast growth factor (FGF), but it also functions as a humoral factor that regulates cell survival and proliferation, vitamin D metabolism, cardiac remodeling progresses to heart failure, and calcium and phosphate homeostasis that correlates with its affect on aging and may serve as a key factor in cancer development with potential tumor suppressor effect. Moreover, Klotho protects against several pathogenic processes in a FGF23-independent manner. These processes include cancer metastasis, vascular calcification, and renal fibrosis. This book covers the recent advances in Klotho research and discusses novel klotho-dependent mechanisms that are clinically relevant in aging and age-related diseases as well as the particular role of Klotho as a target for potential therapeutics.

Über den Autor

[...].nat. Mentor Sopjani, is a biologist and an expert in molecular biology of the cell as well as molecular physiology. His main research interest is focused in defining molecular mechanisms of suicidal erythrocyte death or eryptosis and revealing the cellular transport proteins regulation by various signaling proteins, including Klotho protein.

Details

Erscheinungsjahr:	2014
Fachbereich:	Allgemeines
Genre:	Biologie , Mathematik , Medizin , Naturwissenschaften , Technik
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
Inhalt:	64 S.
ISBN-13:	9783659506246
ISBN-10:	3659506249
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Autor:	Sopjani, Mentor
Hersteller:	LAP LAMBERT Academic Publishing
Verantwortliche Person für die EU:	OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, D-66111 Saarbrücken, info@akademikerverlag.de
Maße:	220 x 150 x 5 mm
Von/Mit:	Mentor Sopjani
Erscheinungsdatum:	04.01.2014
Gewicht:	0,113 kg