Kazuhiko Takehara: Systemic Sclerosis

Cover: 9784431566809 | Systemic Sclerosis | Kazuhiko Takehara (u. a.) | Taschenbuch | viii

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Sprache: Englisch

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Beschreibung

This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.

Über den Autor

Dr. Kazuhiko Takehara

Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan

Dr. Manabu Fujimoto

Department of Dermatology, University of Tsukuba, Japan

Dr. Masataka Kuwana

Department of Allergy and Rheumatology, Nippon Medical School, Japan

Zusammenfassung

Provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma)

Presents a variety of new evidence suggestive of the pathogenesis of scleroderma

Covers clinical research regarding biomarkers and autoantibodies for scleroderma

Inhaltsverzeichnis

1.- Fibrosis: overview 2.- Autoimmunity in systemic sclerosis: Overview 3.- Endothelial progenitor cell 4.- Animal models of systemic sclerosis 5.- Genetics of Systemic Sclerosis 6.- Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis 7.- Interleukin-6 in the Pathogenesis of Systemic Sclerosis 8.- Epigenetics 9.- Transforming Growth Factor-ß and Connective Tissue Growth Factor 10.- Endothelin 11.- The Role of B cells in Systemic Sclerosis 12.- Fli1 13.- Biomarker 14.- Autoantibodies in Systemic Sclerosis

Details

Erscheinungsjahr:	2018
Fachbereich:	Andere Fachgebiete
Genre:	Importe , Medizin
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Inhalt:	viii 247 S. 7 s/w Illustr. 21 farbige Illustr. 247 p. 28 illus. 21 illus. in color.
ISBN-13:	9784431566809
ISBN-10:	4431566805
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Redaktion:	Takehara, Kazuhiko Fujimoto, Manabu Kuwana, Masataka
Herausgeber:	Kazuhiko Takehara/Manabu Fujimoto/Masataka Kuwana
Hersteller:	Springer Springer Japan KK
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	235 x 155 x 14 mm
Von/Mit:	Kazuhiko Takehara (u. a.)
Erscheinungsdatum:	31.03.2018
Gewicht:	0,44 kg