AMPK in the regulation of autophagy, cance...

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Sprache: Englisch

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Beschreibung

The nutrient and energy sensor AMP-activated protein Kinase regulates cellular and whole-body energy homeostasis through stimulating catabolic ATP-generating and suppressing anabolic ATP-consuming pathways thereby helping cells survive during energy starvation. AMPK plays an important role in autophagy induction in response to starvation, a process that involves phosphorylating TSC2 and mTOR activation. Recent advances indicate the kinase also to exert tumor suppressor activity by stimulating apoptosis, autophagy and cell growth and proliferation. AMPK can be used to protect from metabolic syndrome. This kinase has previously been demonstrated to be either directly or indirectly involved in the regulation of numerous carriers, channels and pumps of high relevance for cellular physiology and pathophysiology. Thus, AMPK provides a necessary link between cellular energy metabolism and cellular transport activity. Better understanding of the AMPK role in the regulation of cell transport under physiological and pathological conditions may represent a potential for developing therapies for many human diseases and disorders, especially cancers.

Über den Autor

[...].nat. Mentor Sopjani, is a biologist and an expert in molecular biology of the cell as well as molecular physiology. His main research interest is focused in defining molecular mechanisms of suicidal erythrocyte death or eryptosis and revealing the cellular transport proteins regulation by various signaling proteins, including Klotho protein.

Details

Erscheinungsjahr:	2014
Genre:	Mathematik , Medizin , Naturwissenschaften , Technik , Technik allg.
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
Inhalt:	76 S.
ISBN-13:	9783659593345
ISBN-10:	3659593346
Sprache:	Englisch
Ausstattung / Beilage:	Paperback
Einband:	Kartoniert / Broschiert
Autor:	Sopjani, Mentor
Hersteller:	LAP LAMBERT Academic Publishing
Verantwortliche Person für die EU:	LAP Lambert Academic Publishing, Brivibas Gatve 197, ?-1039 Riga, customerservice@vdm-vsg.de
Maße:	220 x 150 x 5 mm
Von/Mit:	Mentor Sopjani
Erscheinungsdatum:	26.08.2014
Gewicht:	0,131 kg