Jie Jack Li: Conquest of Invisible Enemies

Cover: 9780197609859 | Conquest of Invisible Enemies | A Human History of Antiviral Drugs

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Beschreibung

In his latest book, science writer and medicinal chemist Jie Jack Li guides readers through the history of viruses, vaccines, and antiviral drugs. Li chronicles the discovery and treatment of HIV/AIDS, hepatitis, influenza, and coronaviruses. Throughout, Li focuses on how viruses have shaped human history and on the individuals who developed treatments.

Über den Autor

Jie Jack Li is the CSO of GenHouse Bio. Previously, he was VP of Discovery Chemistry at ChemPartner, an Associate Professor of Chemistry at the University of San Francisco, and a Medicinal Chemist at Pfizer and Bristol-Myers Squibb. He has authored or edited over 30 books, including Blockbuster Drugs (Oxford University Press, 2014), which won the 2015 Alpha Sigma Nu Science Book Award.

Inhaltsverzeichnis

Preface

Chapter 1. Virus Shaping History and Discovery of Virus

1.1 Virus shaping history

1.1.1 Tulipomania: bubbles of bulbs

1.1.2 The fall of old Mexico and Peru

1.1.3 Succession of thrones

1.1.4 The Louisiana Purchase

1.2 Discovery of virus

1.2.1 The gem theory

1.2.2 Discovery of virus

1.2.3 Cancer-causing viruses

1.2.4 Discovery of retrovirus

Chapter 2. HIV/AIDS Drugs, Transforming a Death Sentence to a Chronic Disease

2.1 Discovery of the virus

2.1.1 A death sentence

2.1.2 Discovery of HIV and the great scientific controversy

2.1.3 The Nobel Prize

2.2 The first ray of hope

2.2.1 Nucleoside antiviral drugs

2.2.2 Non-nucleoside reverse transcriptase inhibitors

2.3 HIV protease inhibitors

2.3.1 HIV protease

2.3.2 First-generation HIV protease inhibitors

2.3.3 Second-generation HIV protease inhibitors

2.4 HIV integrase inhibitors

2.5 HIV Entry Inhibitors

2.5.1 HIV fusion inhibitors

2.5.2 CCR5 inhibitors

2.6 Triumph of modern medicine

Chapter 3. Hepatitis Drugs

3.1 Hepatitis A virus

3.1.1 Discovery of hepatitis A virus

3.1.2 Hepatitis A vaccines

3.2 Hepatitis B virus

3.2.1 Discovery of hepatitis B virus

3.2.2 Hepatitis B vaccines

3.2.3 Hepatitis B drugs

3.3 Hepatitis C virus

3.3.1 Discovery of Hepatitis C virus

3.3.2 Hepatitis C virus NS3/4A protease inhibitors

3.3.3 Hepatitis C virus NS5A replication complex inhibitors

3.3.4 Hepatitis C virus NS5B polymerase inhibitors

3.4 Triumph of modern medicines

Chapter 4. Influenza: A Perennial Killer

4.1 Influenza, a perennial killer

4.2 A virus that changed the world: the 1918 Spanish flu pandemic

4.3 Discovery of the influenza virus

4.4 Influenza vaccines

4.4.1 History of vaccination

4.4.2 History of influenza vaccines

4.4.3 Influenza vaccines today

4.5 Influenza drugs

4.5.1 M2 inhibitors

4.5.2 Influenza virus neuraminidase inhibitors

4.5.3 Cap-dependent endonuclease [...] inhibitor

Chapter 5. Coronaviruses

5.1 Coronavirus Drugs

5.1.1. SARS

5.1.2. MARS

5.1.3. SARS-CoV-2

5.2 COVID-19 Vaccines

5.2.1. Pfizer/Biotech's mRNA vaccine

5.2.2. Johnson and Johnson's viral vector vaccine

5.3 COVID-19 Drugs

5.3.1. Remdesivir (Veklury)

5.3.2. Dexamethasone

Chapter 6. Closing Remarks

Bibliography

Chemical Structures of Antiviral Drugs

Details

Erscheinungsjahr:	2023
Fachbereich:	Toxikologie
Genre:	Importe , Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Inhalt:	Gebunden
ISBN-13:	9780197609859
ISBN-10:	0197609856
Sprache:	Englisch
Einband:	Gebunden
Autor:	Li, Jie Jack
Hersteller:	Oxford University Press Inc
Verantwortliche Person für die EU:	Libri GmbH, Europaallee 1, D-36244 Bad Hersfeld, gpsr@libri.de
Maße:	229 x 151 x 24 mm
Von/Mit:	Jie Jack Li
Erscheinungsdatum:	23.02.2023
Gewicht:	0,398 kg

Artikel-ID: 122044476

Über den Autor

Inhaltsverzeichnis

Preface

Chapter 1. Virus Shaping History and Discovery of Virus

1.1 Virus shaping history

1.1.1 Tulipomania: bubbles of bulbs

1.1.2 The fall of old Mexico and Peru

1.1.3 Succession of thrones

1.1.4 The Louisiana Purchase

1.2 Discovery of virus

1.2.1 The gem theory

1.2.2 Discovery of virus

1.2.3 Cancer-causing viruses

1.2.4 Discovery of retrovirus

Chapter 2. HIV/AIDS Drugs, Transforming a Death Sentence to a Chronic Disease

2.1 Discovery of the virus

2.1.1 A death sentence

2.1.2 Discovery of HIV and the great scientific controversy

2.1.3 The Nobel Prize

2.2 The first ray of hope

2.2.1 Nucleoside antiviral drugs

2.2.2 Non-nucleoside reverse transcriptase inhibitors

2.3 HIV protease inhibitors

2.3.1 HIV protease

2.3.2 First-generation HIV protease inhibitors

2.3.3 Second-generation HIV protease inhibitors

2.4 HIV integrase inhibitors

2.5 HIV Entry Inhibitors

2.5.1 HIV fusion inhibitors

2.5.2 CCR5 inhibitors

2.6 Triumph of modern medicine

Chapter 3. Hepatitis Drugs

3.1 Hepatitis A virus

3.1.1 Discovery of hepatitis A virus

3.1.2 Hepatitis A vaccines

3.2 Hepatitis B virus

3.2.1 Discovery of hepatitis B virus

3.2.2 Hepatitis B vaccines

3.2.3 Hepatitis B drugs

3.3 Hepatitis C virus

3.3.1 Discovery of Hepatitis C virus

3.3.2 Hepatitis C virus NS3/4A protease inhibitors

3.3.3 Hepatitis C virus NS5A replication complex inhibitors

3.3.4 Hepatitis C virus NS5B polymerase inhibitors

3.4 Triumph of modern medicines

Chapter 4. Influenza: A Perennial Killer

4.1 Influenza, a perennial killer

4.2 A virus that changed the world: the 1918 Spanish flu pandemic

4.3 Discovery of the influenza virus

4.4 Influenza vaccines

4.4.1 History of vaccination

4.4.2 History of influenza vaccines

4.4.3 Influenza vaccines today

4.5 Influenza drugs

4.5.1 M2 inhibitors

4.5.2 Influenza virus neuraminidase inhibitors

4.5.3 Cap-dependent endonuclease [...] inhibitor

Chapter 5. Coronaviruses

5.1 Coronavirus Drugs

5.1.1. SARS

5.1.2. MARS

5.1.3. SARS-CoV-2

5.2 COVID-19 Vaccines

5.2.1. Pfizer/Biotech's mRNA vaccine

5.2.2. Johnson and Johnson's viral vector vaccine

5.3 COVID-19 Drugs

5.3.1. Remdesivir (Veklury)

5.3.2. Dexamethasone

Chapter 6. Closing Remarks

Bibliography

Chemical Structures of Antiviral Drugs

Details

Erscheinungsjahr:	2023
Fachbereich:	Toxikologie
Genre:	Importe , Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Inhalt:	Gebunden
ISBN-13:	9780197609859
ISBN-10:	0197609856
Sprache:	Englisch
Einband:	Gebunden
Autor:	Li, Jie Jack
Hersteller:	Oxford University Press Inc
Verantwortliche Person für die EU:	Libri GmbH, Europaallee 1, D-36244 Bad Hersfeld, gpsr@libri.de
Maße:	229 x 151 x 24 mm
Von/Mit:	Jie Jack Li
Erscheinungsdatum:	23.02.2023
Gewicht:	0,398 kg

Artikel-ID: 122044476

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