Charisse Litchman: Desmoid Tumors

Cover: 9789400793033 | Desmoid Tumors | Charisse Litchman | Taschenbuch | xi | Englisch

Rückseite: 9789400793033 | Desmoid Tumors | Charisse Litchman | Taschenbuch | xi | Englisch

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Sprache: Englisch

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Beschreibung

Desmoid Tumors (DT), also called Aggressive Fibromatoses, are a rare fibroblastic proliferative disease, with an incidence of 2 to 4 new cases per million people per year. Despite the absence of a metastatic potential, DT cause significant morbidity and at times mortality due to its locally invasive behaviour. The anatomical locations can be abdominal, extra-abdominal (often in the extremities) and intra-abdominal. This book is the first manuscript dedicated entirely to Desmoid Tumors. Written by prominent clinicians, researchers and advocacy group experts, patients and professionals alike will find this to be a comprehensive review. Clinical presentation, imaging guidelines and treatment paradigms are highlighted. Both the sporadic and heredity forms (Familial Adenomatous Polyposis) will be discussed. A thorough discussion on the unique issues in children with DT is included. A portion of the book will address the role of the APC gene, the ¿-catenin protein and the role of mutations in the genesis of DT. Emerging cutting edge research techniques will be revealed. Also included is a thoughtful discussion on the controversial labelling of Desmoid Tumors as benign and the consequences of such a designation. The role of advocacy groups in supporting research and in promoting awareness of rare diseases such as DT will be outlined. This book will serve as basis to prepare clinicians, researchers and patients to embark on the quest for a cure for Desmoid Tumors.

Zusammenfassung

First manuscript on desmoid tumors

World renowned authors

Encompasses topics of relevance to clinicians, scientific researchers and advocacy groups

Provides concrete guidance for treatment planning

Addresses molecular aberrations driving the inception of DT

Includes supplementary material: [...]

Inhaltsverzeichnis

1. Introduction.- Part I The identification and treatment of Desmoid Tumors.- 2. Clinical presentation of Desmoid Tumors.- 3. Pathology of Desmoid Tumors.- 4. APC/ ß-catenin degeneration in Desmoid Tumors: important implications for diagnosis, prognosis, and therapy.- 5. Imaging Techniques in Desmoid Tumors.- 6. Surgical management of DesmoidTumors.- 7. Systemic Therapy of Desmoid Tumors.- 8. Radiation Therapy for Desmoid Tumors.- 9. Interventional Radiology.- Part 2 Special Populations with Desmoid Tumors.- 10. Desmoid Disease in Familial Adenomatous Polyposis.- 11. Desmoid Tumor in Children and Adolescents: The Influence of Age.- Part 3 Considerations for current and future advancement in the search for a cure.- 12. Microarrays and High-Throughput Sequencing in Desmoid Type Fibromatosis and Scar.- 13. Desmoid Tumors: Are they benign or malignant?- 14. The Role of Advocacy Groups in Rare Tumors such as Desmoid Tumors.- Index.

Details

Erscheinungsjahr:	2014
Fachbereich:	Andere Fachgebiete
Genre:	Importe , Medizin
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Inhalt:	xi 221 S.
ISBN-13:	9789400793033
ISBN-10:	9400793030
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Redaktion:	Litchman, Charisse
Herausgeber:	Charisse Litchman
Hersteller:	Springer Netherland Springer Netherlands
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	235 x 155 x 13 mm
Von/Mit:	Charisse Litchman
Erscheinungsdatum:	28.11.2014
Gewicht:	0,365 kg