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Determination of the Antiretroviral Drug Lamivudine
by Potentiometric Titration using All Solid State Graphite Based Iodide Selective Electrode
Taschenbuch von Shemsia Mohamed Hudie (u. a.)
Sprache: Englisch

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Beschreibung
A solid-state iodide selective electrode with Ag2S-AgI adsorbed on graphite rod, recovered from a dry cell, was prepared and validated for its typical response characteristics with an objective to develop a potentiometric titration system for rapid measurements of Lamuvidine (LMV) in tablets used as an antiretroviral drug for Hepatis B and HIV patients. The partial validationexhibited typical response values of linear range of 10-6 to 10-1 M iodide and a slope 57.57 mV/decade which reasonably agreed with early data from our [...] basis of LMV determination is its oxidation by excess bromine generated from bromate-bromide mixture. The unreacted bromine oxidized the added excess iodide to iodine. The amount of bromine consumed by LMV, the basis of its determination, was determined by subtracting the back-titrated iodine with thiosulphate whose end-point was located potentiometrically with the solid state iodide selective electrode against a reference electrode. The iodometric back titration provided for the indirect determination of 1-30 mg LMV in turbid tablet test solutions.
A solid-state iodide selective electrode with Ag2S-AgI adsorbed on graphite rod, recovered from a dry cell, was prepared and validated for its typical response characteristics with an objective to develop a potentiometric titration system for rapid measurements of Lamuvidine (LMV) in tablets used as an antiretroviral drug for Hepatis B and HIV patients. The partial validationexhibited typical response values of linear range of 10-6 to 10-1 M iodide and a slope 57.57 mV/decade which reasonably agreed with early data from our [...] basis of LMV determination is its oxidation by excess bromine generated from bromate-bromide mixture. The unreacted bromine oxidized the added excess iodide to iodine. The amount of bromine consumed by LMV, the basis of its determination, was determined by subtracting the back-titrated iodine with thiosulphate whose end-point was located potentiometrically with the solid state iodide selective electrode against a reference electrode. The iodometric back titration provided for the indirect determination of 1-30 mg LMV in turbid tablet test solutions.
Über den Autor
I am a highly enthusiastic professional always trying hard to fulfill my goals to grow professionally and spritually which is indispensable for the well being of human kind. born and grown up in a beautiful town Bahirdar, Ethiopia. Currently i am a lecturer in analytical chemistry,at one of the oldest universities in Ethiopia, Haremaya university.
Details
Erscheinungsjahr: 2011
Genre: Ratgeber, Sachbuch
Rubrik: Ratgeber
Thema: Briefe, Bewerbungen, Wiss. Arbeiten, Rhetorik
Medium: Taschenbuch
Inhalt: 60 S.
ISBN-13: 9783846528778
ISBN-10: 3846528773
Sprache: Englisch
Ausstattung / Beilage: Paperback
Einband: Kartoniert / Broschiert
Autor: Hudie, Shemsia Mohamed
Moges, Ghirma
Hersteller: LAP LAMBERT Academic Publishing
Verantwortliche Person für die EU: LAP Lambert Academic Publishing, Brivibas Gatve 197, ?-1039 Riga, customerservice@vdm-vsg.de
Maße: 220 x 150 x 4 mm
Von/Mit: Shemsia Mohamed Hudie (u. a.)
Erscheinungsdatum: 24.10.2011
Gewicht: 0,107 kg
Artikel-ID: 106746472
Über den Autor
I am a highly enthusiastic professional always trying hard to fulfill my goals to grow professionally and spritually which is indispensable for the well being of human kind. born and grown up in a beautiful town Bahirdar, Ethiopia. Currently i am a lecturer in analytical chemistry,at one of the oldest universities in Ethiopia, Haremaya university.
Details
Erscheinungsjahr: 2011
Genre: Ratgeber, Sachbuch
Rubrik: Ratgeber
Thema: Briefe, Bewerbungen, Wiss. Arbeiten, Rhetorik
Medium: Taschenbuch
Inhalt: 60 S.
ISBN-13: 9783846528778
ISBN-10: 3846528773
Sprache: Englisch
Ausstattung / Beilage: Paperback
Einband: Kartoniert / Broschiert
Autor: Hudie, Shemsia Mohamed
Moges, Ghirma
Hersteller: LAP LAMBERT Academic Publishing
Verantwortliche Person für die EU: LAP Lambert Academic Publishing, Brivibas Gatve 197, ?-1039 Riga, customerservice@vdm-vsg.de
Maße: 220 x 150 x 4 mm
Von/Mit: Shemsia Mohamed Hudie (u. a.)
Erscheinungsdatum: 24.10.2011
Gewicht: 0,107 kg
Artikel-ID: 106746472
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