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Cover: 9786202311694 | Impact of Epigenetic modifications and alcohol on different brain area
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Impact of Epigenetic modifications and alcohol on different brain area
Taschenbuch von Prabha Rajput (u. a.)
Sprache: Englisch

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Beschreibung
Global hypomethylation of DNA resulting from a reduction in (S-adenosyl methionine) SAM levels. SAM levels are reduced as a result of an alcohol-induced reduction in folate and the inhibition of methionine synthase. At the same time, SAH levels are increased which inhibits DNMT. Histone modification that is associated with an increase in NADH levels caused by alcohol metabolism. The increase in NADH affects SIRT1 activity, leading to gene expression or silencing. Production of ROS, which affects the expression of inflammatory genes, and acetate, which is used in extra-hepatic tissues to produce acetyl-CoA. The latter then is used in histone acetylation by HATs. These epigenetic changes resulting from chronic alcohol consumption can lead to organ pathology. Understanding the exact nature of the epigenetic changes will help design medication for the treatment or alleviation of alcohol-induced organ damage
Global hypomethylation of DNA resulting from a reduction in (S-adenosyl methionine) SAM levels. SAM levels are reduced as a result of an alcohol-induced reduction in folate and the inhibition of methionine synthase. At the same time, SAH levels are increased which inhibits DNMT. Histone modification that is associated with an increase in NADH levels caused by alcohol metabolism. The increase in NADH affects SIRT1 activity, leading to gene expression or silencing. Production of ROS, which affects the expression of inflammatory genes, and acetate, which is used in extra-hepatic tissues to produce acetyl-CoA. The latter then is used in histone acetylation by HATs. These epigenetic changes resulting from chronic alcohol consumption can lead to organ pathology. Understanding the exact nature of the epigenetic changes will help design medication for the treatment or alleviation of alcohol-induced organ damage
Über den Autor
Prabha Rajput, PhD, è ricercatrice presso l'IIT (BHU) di Varanasi, India. Ha lavorato come assistente alla Rajiv Academy of Pharmacy, Mathura. Ha conseguito un Master in Farmacologia e Tossicologia presso il National Institute of Pharmaceutical Education and Research (NIPER), Guwahati (Assam), India e una laurea in Farmacologia.
Details
Erscheinungsjahr: 2018
Fachbereich: Toxikologie
Genre: Importe, Medizin
Rubrik: Wissenschaften
Medium: Taschenbuch
Inhalt: 76 S.
ISBN-13: 9786202311694
ISBN-10: 620231169X
Sprache: Englisch
Einband: Kartoniert / Broschiert
Autor: Rajput, Prabha
Kumar, Manish
Hersteller: Scholars' Press
Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, D-22848 Norderstedt, info@bod.de
Maße: 220 x 150 x 5 mm
Von/Mit: Prabha Rajput (u. a.)
Erscheinungsdatum: 13.06.2018
Gewicht: 0,131 kg
Artikel-ID: 113978302
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