Before the rise of Rome, the Greeks and Carthaginians were, for centuries, the two most powerful nations of the Western Mediterranean. From the Pillars of Hercules to Sicily and Cyrenaica, the Greeks and the Carthaginians founded cities, created trade routes, interacted with each other as competitors and collaborators, and often went to war. However, the long conflict between the Western Greeks and the Carthaginians has been neglected by modern historians, even though the wars between them are definitely among the greatest, longest, and most dramatic clashes of great powers in history when it comes to the historical breadth and the forces involved. Sotirios Drokalos gives these epic events the attention they [...] competition and conflicts between Greeks and Phoenicians in the West began by the time of the first colonizations during the eighth century BCE and the development of the cultural and economic activity of the two cultures. They intensified after the Greek colonies'' consolidation and Carthage''s rise as the most significant Phoenician city and a commercial empire during the sixth century BCE. Especially from the beginning of the fifth century BCE and for the next roughly 200 years, the Western Mediterranean was the field of a ruthless bipolar confrontation between the Greeks of the West and the Carthaginians, marked by the actions of remarkable personalities of the ancient world. This historical clash, apart from the vast and bloody battles, the invasions of one side by the other, the sieges and the mass slaughters, also included elements of cultural interaction and exchange, consisting essentially of a practical test of constitutions, social systems, and political views. Under this prism, studying that tumultuous era could be necessary today to better understand Mediterranean and European historical evolution.